Transcriptome analysis of leukocytes from sarcoma patients for helpful biomarkers

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670544
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: SAITO Toshiyuki 国立研究開発法人放射線医学総合研究所, 重粒子医科学センター, 主任研究員 (90205667)
• Co-Investigator(Kenkyū-buntansha): KOBASHI Gen 獨協医科大学, 医学部, 教授 (60270782)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: がん / 骨軟部腫瘍 / 骨肉腫 / 脊索腫 / 遺伝子発現 / 血液 / バイオマーカー / トランスクリプトーム

Outline of Final Research Achievements

To obtain novel biomarkers helpful for diagnosis of sarcomas or musculoskeletal tumors, leukocytes from 6 cases and 4 controls were subjected to a high accuracy large-scale gene expression analysis of 8,919 mRNAs revealed difference of transcriptome between the cases and controls. It is suggested that studies focusing on differentially-expressed transcripts might discriminate cases from controls with high accuracy in the future.

Free Research Field

分子遺伝学