2014 Fiscal Year Annual Research Report
| Project/Area Number |
25670556
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| Research Institution | Osaka University |
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Principal Investigator |
石井 秀始 大阪大学, 医学(系)研究科(研究院), 特任教授(常勤) (10280736)
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| Co-Investigator(Kenkyū-buntansha) |
今野 雅允 大阪大学, 医学(系)研究科(研究院), 寄附講座助教 (80618207)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 再生医療 / 再生医学 / 細胞・組織 / 発生・分化 / トランスレーショナルリサーチ |
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| Outline of Annual Research Achievements |
他の消化器臓器への応用解析：上記の成果を膵以外の消化器臓器の幹細胞(肝・腸）へ応用した。肝では肝細胞の網羅的発現解析を実施、分化細胞の発現と比較してコア転写因子群を同定した。同定したリストからウイルスベクター搭載、iPS転写因子(Oct3,Sox2, Klf4, c-Myc)搭載ウイルスベクターを同時に導入し、iPSコロニー数の減少(GFPのみの対照と比較）を指標としてβ細胞コアネットワーク構成転写因子を同定した(肝臓に対するiPS干渉法)。また腸では、腸管細胞（HCT)の網羅的発現解析、コア転写因子群を同定、iPS転写因子を同時に導入、コロニ-数を減少を指標としてβ細胞コアネットワーク構成転写因子を同定した(腸管に対するiPS干渉法）。
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Research Products
(11 results)
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[Journal Article] Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen.2014
Author(s)
Yoshioka, Y., Kosaka, N., Konishi, Y., Ohta, H., Okamoto, H., Sonoda, H., Nonaka, R., Yamamoto, H., Ishii, H., Mori, M., Furuta, K., Nakajima, T., Hayashi, H., Sugisaki, H., Higashimoto, H., Kato, T., Takeshita, F., Ochiya, T.
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Journal Title
Nat. Commun.
Volume: 7
Pages: 3591
DOI
Peer Reviewed
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[Journal Article] LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer.2014
Author(s)
Lovat, F., Ishii, H., Schiappacassi, M., Fassan, M., Barbareschi, M., Galligioni, E., Gasparini, P., Baldassarre, G., Croce, CM., Vecchione, A.
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Journal Title
Oncotarget
Volume: 5
Pages: 970-977
Peer Reviewed
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[Journal Article] CD10 as a novel marker of therapeutic resistance and cancer stem cells in head and neck squamous cell carcinoma.2014
Author(s)
Fukusumi, T., Ishii, H., Konno, M., Yasui, T., Nakahara, S., Takenaka, Y., Yamamoto, Y., Nishikawa, S., Kano, Y., Ogawa, H., Hasegawa, S., Hamabe, A., Haraguchi, N., Doki, Y., Mori, M., Inohara, H.
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Journal Title
Br. J. Cancer
Volume: 111
Pages: 506-514
DOI
Peer Reviewed
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[Journal Article] MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer.2014
Author(s)
Hasegawa, S., Eguchi, H., Nagano, H., Konno, M., Tomimaru, Y., Wada, H., Hama, N., Kawamoto, K., Kobayashi, S., Nishida, N., Koseki, J., Nishimura, T., Gotoh, N., Ohno, S., Yabuta, N., Nojima, H., Mori, M., Doki, Y., Ishii, H.
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Journal Title
Br J. Cancer
Volume: 111
Pages: 1572-1580
DOI
Peer Reviewed
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[Journal Article] Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis.2014
Author(s)
Hamabe, A., Hirofumi, Y., Konno, M., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Mizushima, T., Nishida, N., Kawamoto, K., Koseki, J., Doki, Y., Mori, M., Ishii, H.
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Journal Title
Cancer Sci.
Volume: 105
Pages: 1100-1108
DOI
Peer Reviewed
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[Journal Article] Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.2014
Author(s)
Hamabe, A., Konno, M.,Tanuma, N., Shima, H., Tsunekuni, K., Kawamoto, K., Nishida, N., Koseki, J.,Mimori, K., Gotho, N., Yamamoto, H., Doki, Y., Mori, M., Ishii, H.
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Journal Title
Proc. Natl. Acad. Sci. U S A.
Volume: 111
Pages: 15526-15531
DOI
Peer Reviewed
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[Journal Article] Cancer Stem Cells of the Digestive System.2014
Author(s)
Colvin, S. H., Nishida, N., Koseki, J., Konno, M., Kawamoto, K., Tsunekuni, K., Doki, Y., Mori, M., Ishii, H.
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Journal Title
Jpn. J. Clin. Oncol.
Volume: 44
Pages: 1141-1149
DOI
Peer Reviewed
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