Identification of novel inducing factors pancreatic beta cells by iPS modified technology

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670556
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Osaka University
• Principal Investigator: ISHII Hideshi 大阪大学, 医学(系)研究科(研究院), 特任教授(常勤) (10280736)
• Co-Investigator(Kenkyū-buntansha): KONNO Masamitsu 大阪大学, 大学院医学系研究科, 寄附講座助教 (80618207)
• Co-Investigator(Renkei-kenkyūsha): MORI Masaki 大阪大学, 大学院医学系研究科, 教授 (70190999) ; MIMORI Koshi 九州大学, 大学病院, 教授 (50322748) ; NAGANO Hiroaki 山口大学, 大学院医学系研究科, 教授 (10294050) ; EGUCHI Hidetoshi 大阪大学, 大学院医学系研究科, 准教授 (90542118)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 再生医療 / 再生医学 / 細胞・組織 / 発生・分化 / トランスレーショナルリサーチ

Outline of Final Research Achievements

To identity critical factors for induction of pancreatic beta cells, we developed novel technology of induced pluripotent stem (iPS) interfering method. The study of gene expression allowed the identification of several factors, which play roles in induction and maintenance of pancreatic beta cells. The present study would open an avenue to new efficient approach for human diabetes.

Free Research Field

外科学