2013 Fiscal Year Final Research Report
The improvement of drug delivery based on the normalization of cancer stroma and its application for the treatment of pancreatic cancer
| Project/Area Number |
25670584
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
OHUCHIDA Kenoki 九州大学, 先端医療イノベーションセンター, 講師 (20452708)
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| Co-Investigator(Kenkyū-buntansha) |
MAEYAMA Ryo 九州大学, 大学病院, 助教研究者 (10611668)
MORIYAMA Taiki 九州大学, 医学研究院, 共同研究員研究者 (70586859)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | 膵がん / 膵星細胞 / 細胞外基質 |
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| Research Abstract |
In the present study, we focused on tumor-related stroma and its remodeling and normalization and mainly investigated the mechanism of cancer-stromal interaction between cancer cells and pancreatic stellate cells. Then, we identified the several molecules, which are related with the extracellular matrices derived from pancreatic stellate cells and found that such matrices affect the invasion and migration of pancreatic cancer cells. These data suggest that the remodeling of cancer stroma by normalization based on the novel molecules may lead to the development of new therapy for pancreatic cancer.
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Research Products
(23 results)
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[Journal Article] Expression of Glucagon.Like Peptide 1 Receptor and Its Effects on Biological Behavior in Pancreatic Neuroendocrine Tumors2014
Author(s)
Ana Ines Cases, Takao Ohtsuka, Minoru Fujino, Noboru Ideno, Shingo Kozono, Ming Zhao, Kenoki Ohuchida, Shinichi Aishima, Masatoshi Nomura, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka
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Journal Title
Pancreas
Volume: 43(1)
Pages: 1-6
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[Journal Article] Kindlin-2 expression in peritumoral stroma is associated with poor prognosis in pancreatic ductal adenocarcinoma2013
Author(s)
Prawej Mahawithitwong, Kenoki Ohuchida, Naoki Ikenaga, Hayato Fujita, Ming Zhao, Shingo Kozono, Koji Shindo, Takao Ohtsuka, Shinichi Aishima, Kazuhiro Mizumoto, Masao Tanaka
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Journal Title
Pancreas
Volume: 42
Pages: 663-9
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[Journal Article] MAL2 expression predicts distant metastasis and short survival in pancreatic cancer2013
Author(s)
Daiki Eguchi, Kenoki Ohuchida, Shingo Kozono, Naoki Ikenaga, Koji Shindo, Lin Cui, Kenji Fujiwara, Shin Akagawa, Takao Ohtsuka, Shunichi Takahata, Shoji Tokunaga, Kazuhiro Mizumoto, Masao Tanaka
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Journal Title
Surgery
Volume: 154(3)
Pages: 573-82
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[Presentation] Expression of Glucagon-like Peptide 1 Recepter and Biological Behavior in Pancreatic Neuroendocrine Tumors2013
Author(s)
Cases A.I., Ohtsuka T, Fujino M, Ideno N, Kzono S, Zhao M, Ikenaga N, Ohuchida K, Oda Y, Mizumoto K, Tanaka M
Organizer
44th Annual Meeting, Miami
Place of Presentation
Ammerican Pancreatic Association
Year and Date
20130000
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[Presentation] Treatment Strategy for Main Duct Intraductal Papillary Mucinous Neoplasms of the Pancreatic Based on the Assessment of Recurrence in the Remnant Pancreas after Resection : A Retrospective Review2013
Author(s)
Tamura K, Ohtsuka T, Ideno N, Aso T, Shindo K, Oda Y, Ohuchida K, Takahata S, Mizumoto K, Tanaka M
Organizer
44th Annual Meeting, Miami, 2013
Place of Presentation
Ammerican Pancreatic Association
Year and Date
20130000
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[Presentation] Clinical Significance of Stromal CD90 and alpha-SMA Expression in Pancreatic Cancer2013
Author(s)
Sada M, Ohuchida K, Fujiwara K, Horioka K, Tanaka T, Zheng B, Cases A.I., Akagawa S, Shindo K, Ohtsuka T, Takahata S, Oda Y, Mizumoto K, Tanaka M
Organizer
44th Annual Meeting, Miami
Place of Presentation
Ammerican Pancreatic Association
Year and Date
20130000
