Application of in-body tissue-engineered heart valve (biovalve) to total artificial heart

2016 Fiscal Year Final Research Report

• Project/Area Number: 25670603
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Sumikura Hirohito 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (20433998)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: バイオバルブ / 全人工心臓 / 人工弁 / 自己組織 / 模擬循環回路

Outline of Final Research Achievements

In this study, a biovalve for total artificial heart was developed using the "in-body tissue architecture" technology. A specially designed acrylic mold was placed in dorsal subcutaneous pouches of goats for 1-2 months. After extraction, the cylindrical mold was removed to obtain the biovalve. We fabricated three different forms of biovalves and evaluated their function in vitro using a mock circulation circuit to determine the optimal biovalve form for total artificial heart. The developed biovalves demonstrated good function in in vitro study. Based on the evaluation results of three kinds of biovalves, the biovalve for total artificial heart was developed.

Free Research Field

医用生体工学