The study of lung regenerative medicine for the damaged lung by iPS cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 25670606
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Chiba Cancer Center (Research Institute) (2015-2016); Chiba University (2013-2014)
• Principal Investigator: YAMAMOTO Takayoshi 千葉県がんセンター(研究所), 呼吸器外科, 医長 (20648349)
• Research Collaborator: SHIINA Yuuki 千葉大学, 大学院医学研究院, 医員 (30782304)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 肺再生 / iPS / マウス / 肺移植

Outline of Final Research Achievements

The purpose is that we differentiate and induce the alveolar type Ⅱ cell. We transplant these cells to disease model mouse by air way and discuss the effect.
In this duration, we could stable passage the mouse iPS cells and human iPS cells and produce the medium to differentiate and induce to the alveolar type Ⅱ cells. And we made the specific gene which could label the SP-C protein.
We now make the ischemic and reperfusion mouse model, we continue to make the experiments of the chronic immunological rejection model mouse by allograft lung transplantation.

Free Research Field

肺再生