Mitochondrian haplotypes and EGFR mutations in Japanese lung cancer patients

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670609
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Kagoshima University
• Principal Investigator: Sato Masami 鹿児島大学, 医学部, 教授 (30250830)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Yoshihiro 鹿児島大学, 医歯学域医学部・歯学部附属病院, 講師 (60381159) ; KARIATSUMARI Kohta 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (20648050) ; Ohtsuka Tsunayuki 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (40464466) ; AOKI Masaya 鹿児島大学, 医歯学域医学系, 助教 (50624996) ; NAGATA Toshiyuki 鹿児島大学, 医学部・歯学部附属病院, 医員 (70611763)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肺癌 / 遺伝子異常 / EGFR / ミトコンドリア / ハプロタイプ

Outline of Final Research Achievements

We examined mitochondrian haplotypes and EGFR mutations in 21 Japanese lung cancer patients. EGFR mutation were observed as follows, EX19 del in 10, L858R in 9 and others in two. In these 21 cases with EGFR mutaions, mitochondrian haplotypes were as follows, D4 in7, B4 in 2, M7a in 3，G　in 2，A　in 1，F　in 1，D5 in　1，N9a　in 1，M7b in　1，B5 in　1, and M9 in 1.
In conclusion, there is no relationship between mitochondrian haplotype and EGFR mutation. However, the number of examined cases was small. Thus future examination will be necessary to obtain final conclusions.

Free Research Field

呼吸器外科