2013 Fiscal Year Final Research Report
A daring attempt to cure glioblastoma by targeting glucose metabolism as a novel target to control glioma stem cells
| Project/Area Number |
25670615
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurosurgery
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | glioma-initiating cell |
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| Research Abstract |
Increased glucose metabolism often occurs in human cancers, the significance of which for cancer cells remains mostly unclear. In this project, we conducted experiments to test the working hypothesis that glucose metabolism has an essential role in the maintenance of glioma stem cells. The results suggested that inhibition of an intracellular molecule presumed to be involved in glucose metabolism might affect the stemness of glioma stem cells, in support of the idea that glucose metabolism is involved in the maintenance of glioma stem cells.
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Research Products
(14 results)
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[Journal Article] JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression2014
Author(s)
Okada M, Sato A, Shibuya K, Watanabe E, Seino S, Suzuki S, Seino M, Narita Y, Shibui S, Kayama T, Kitanaka C
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Journal Title
Int J Oncol
Volume: 44
Pages: 591-599
Peer Reviewed
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