2014 Fiscal Year Final Research Report
Clarification of the crosstalk between bone and brain.
| Project/Area Number |
25670637
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OKAWA Atsushi 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (30251507)
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| Co-Investigator(Kenkyū-buntansha) |
ASAO Yoshinori 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50345279)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 骨代謝 / 臓器連関 |
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| Outline of Final Research Achievements |
To evaluate the physiological role of renin-angiotensin system (RAS) in bone metabolism, we analyzed bone-specific RAS related gene deficient (CKO) mice. These mice showed low bone mass via decreasing of the bone formation, and the expression of bone formation markers in long bone were reduced. Furthermore, CKO mice decreased body weight compared with WT mice. These results suggest that RAS in bone metabolism regulates bone formation.
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| Free Research Field |
医歯薬学
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