In vivo imaging for joint, blood, and cerebrospinal fluid

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670662
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Spinal Injuries Center
• Principal Investigator: SHIBA KEIICHIRO 独立行政法人労働者健康福祉機構総合せき損センター(研究部), その他部局等, 研究員 (90574137)
• Co-Investigator(Renkei-kenkyūsha): OKADA SEIJI 九州大学, 医学研究院, 准教授 (30448435)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: バイオイメージング

Outline of Final Research Achievements

The fluid biology including blood, cerebrospinal and joint fluid, is closely related with the pathophysiology of most disease in the field of orthopedic surgery. However, the evaluating method for it is relatively difficult due to a lack of basic researches using animal model. We attempted to establish in vivo imaging of fluid biology by using firefly luciferase and artificial albumin. We demonstrated that in vivo imaging of accumulated inflammatory cells can predict the prognosis in the hyperacute phase of spinal cord injury.

Free Research Field

医歯薬学