Enhanced recovery after surgery induced by pro-resolving mediators and autophagy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670674
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Kageyama Kyouko 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (80347468)
• Co-Investigator(Kenkyū-buntansha): Sawa Teiji 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10206013) ; Nakajima Yasufumi 関西医科大学, 医学部, 教授 (70326239)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 術後回復力強化 / microRNA / 炎症消退脂質分子 / オートファジー

Outline of Final Research Achievements

Our research aimed to elucidate the contributions of the disappearance of inflammatory responses of pro-resolving mediators and the induction of autophagy on the mechanism of Enhanced Recovery After Surgery (ERAS).
Firstly, we divided C57BL/6 mice into control and starvation groups and observed the alterations of hepatic cells. Thereafter, we identified the possibility of suppressing hepatic cell autophagy in a starved state, which was induced by Resolvin. Finally, we examined the microRNAs associated with hepatic cell autophagy in a starved state by conducting comprehensive microRNA analysis with a next generation sequencer. To the present, we have not identified microRNAs showing significant differences correlated with hepatic cell autophagy.

Free Research Field

術後回復力強化