2014 Fiscal Year Final Research Report
Analysis of androgen-regulated natural antisense RNA for the diagnosis and treatment of prostate cancer
| Project/Area Number |
25670678
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
URANO Tomohiko 東京大学, 医学部附属病院, 講師 (20334386)
INOUE Satoshi 東京大学, 医学部附属病院, 特任教授 (40251251)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 分子腫瘍学 / 内分泌学 / 病態医化学 / ゲノム医科学 |
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| Outline of Final Research Achievements |
In this study, we investigated the role of antisense RNA, expressed in the antisense direction of protein coding gene, among long non-coding RNAs regulated by androgen receptor (AR) in prostate cancer. First, we identified a novel androgen-inducible non-coding RNA situated in the antisense region of CTBP1 gene, and then we named it as CTBP1-AS. We found the androgen-dependent accumulation of this antisense RNA in the nucleus of prostate cancer cells and the epigenetic mechanism for prostate cancer progression by CTBP1-AS. We also identified additional antisense RNAs regulated by androgen using directional RNA-seq analysis in prostate cancer cells.
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| Free Research Field |
内分泌学
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