2014 Fiscal Year Final Research Report
A genetic screen in Drosophila for regulators of human prostate cancer progression.
| Project/Area Number |
25670688
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIKI Tsuneharu 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10243239)
UEDA Takashi 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50601598)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 前立腺癌 / 癌転移モデル / ショウジョウバエ |
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| Outline of Final Research Achievements |
To uncover the mechanism by which human prostate cancer progresses, we performed a genetic screen for regulators of human prostate cancer progression using the Drosophila accessory gland, a functional homolog of the mammalian prostate. Cell growth and migration of secondary cells in the adult male accessory gland were found to be regulated by Drosophila homologues of regulators of human prostate cancer progression. Using this screening system, we identified three genes that promoted growth and migration of secondary cells. The human homologues of these candidate genes were expressed in human prostate cancer cells and promoted replication and invasiveness in these cells. These findings suggest that the development of the Drosophila accessory gland and human prostate cancer cell growth and invasion are partly regulated through a common mechanism. The screening system using the accessory gland can be a useful tool for uncovering the mechanisms of human prostate cancer progression.
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| Free Research Field |
泌尿器科学
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