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2014 Fiscal Year Annual Research Report

子宮頸癌発生過程とHLAクラスIIアレルに関する研究

Research Project

Project/Area Number 25670693
Research InstitutionUniversity of Tsukuba

Principal Investigator

吉川 裕之  筑波大学, 医学医療系, 教授 (40158415)

Co-Investigator(Kenkyū-buntansha) 前田 平生  埼玉医科大学, 医学部, 教授 (30134597)
Project Period (FY) 2013-04-01 – 2015-03-31
Keywords子宮頸がん / ヒトパピローマウイルス(HPV) / ヒト白血球型抗原(HLA)
Outline of Annual Research Achievements

日本人においてHLAクラスIIと子宮頸癌もしくはその前駆病変の関連について研究することを目的として、健常者341名、CIN1/2患者591名、CIN3/子宮頸癌321名を含む1253名の日本人女性を対象として、横断的研究を行い、加えて、CIN1/2患者のうち454名については、経過観察し、CIN 3への進展とHLAクラスIIとの関連についてコホート研究も行った。結果は次のようになった。HLAクラスIIアレル頻度は、健常者とCIN1/2患者では同様であった。健常者およびCIN1/2患者と比べて、DRB1*0901、DRB1*1302の頻度はCIN3/子宮頸癌患者に比べて、有意に低かった(P=0.00001, P=0.006)。454名のCIN1/2患者の経過観察データからは、10年間のCIN3への進展リスクは、DRB1*1302患者で有意に減少していた(3.2% vs. 23.7%, P=0.03)。DRB1*0901など他のHLAクラスIIアレルとは関連がなかった。横断的研究とコホート研究により、DRB1*1302アレルがCIN3/子宮頸癌への進展を予防する効果を有することを示した。他のHLAクラスIIと子宮頸癌との関連性については確認できなかった。

  • Research Products

    (24 results)

All 2015 2014

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (14 results) (of which Invited: 2 results)

  • [Journal Article] Administration of standard-dose BEP regimen (bleomycin + etoposide + cisplatin) is essential for treatment of ovarian yolk sac tumor.2015

    • Author(s)
      Satoh T, Aoki Y, Kasamatsu T, Ochiai K, Takano M, Watanabe Y, Kikkawa F, Takeshima N, Hatae M, Yokota H, Saito T, Yaegashi N, Kobayashi H, Baba T, Kodama S, Saito T, Sakuragi N, Sumi T, Kamura T and Yoshikawa H.
    • Journal Title

      Eur J Cancer.

      Volume: 51 Pages: 340-351

    • DOI

      10.1016/j.ejca.2014.12.004. Epub 2015 Jan 2.

    • Peer Reviewed
  • [Journal Article] Increased CD11b+Gr-1+ cell population in the placenta after infection with Toxoplasma gondii.2015

    • Author(s)
      Takeshima K, Nabekura T, Nagamune K, Hamada H, Yoshikawa H, Shibuya A.
    • Journal Title

      Microbiol Immunol.

      Volume: 59 Pages: 95-98

    • DOI

      10.1111/1348-0421.12225.

    • Peer Reviewed
  • [Journal Article] Glucocorticoids facilitate the transcription from the human cytomegalovirus major immediate early promoter in glucocorticoid receptor- and nuclear factor-I-like protein-dependent manner.2015

    • Author(s)
      Inoue-Toyoda M, Kato K, Nagata K, Yoshikawa H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 458 Pages: 180-185

    • DOI

      10.1016/j.bbrc.2015.01.091. Epub 2015 Jan 29.

    • Peer Reviewed
  • [Journal Article] Pathology-oriented treatment strategy of malignant ovarian tumor in pregnant women: analysis of 41 cases in Japan.2014

    • Author(s)
      Morikawa A, Ueda K, Takahashi K, Fukunaga M, Iwashita M, Kobayashi Y, Takechi K, Umezawa S, Terauchi F, Kiguchi K, Aoki D, Nomura H, Yoshikawa H, Satoh T, Jobo T, Fujiwara H, Takei Y, Kamoi S, Terao Y, Isonishi S.
    • Journal Title

      Int J Clin Oncol.

      Volume: 19 Pages: 1074-1079

    • DOI

      10.1007/s10147-014-0669-3. Epub 2014 Feb 18.

    • Peer Reviewed
  • [Journal Article] Moesin overexpression is a unique biomarker of adenomyosis.2014

    • Author(s)
      Ohara R, Michikami H, Nakamura Y, Sakata A, Sakashita S, Satomi K, Shiba-Ishii A, Kano J, Yoshikawa H, Noguchi M.
    • Journal Title

      Pathol Int.

      Volume: 64 Pages: 115-122

    • DOI

      10.1111/pin.12148.

    • Peer Reviewed
  • [Journal Article] Efficacy of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical intraepithelial neoplasia and cervical infection in young Japanese women: open follow-up of a randomised clinical trial up to four years post-vaccination.2014

    • Author(s)
      Konno R, Yoshikawa H, Okutani M, Quint W, Pemmaraju S, Lin L, Struyf F.
    • Journal Title

      Hum Vaccin Immunother.

      Volume: 10 Pages: 1781-1794

    • DOI

      10.4161/hv.28712.

    • Peer Reviewed
  • [Journal Article] Monitoring the impact of a national HPV vaccination program in Japan (MINT study): rationale, design and methods.2014

    • Author(s)
      Matsumoto K, Yaegashi N, Iwata T, Ariyoshi K, Fujiwara K, Shiroyama Y, Usami T, Kawano Y, Horie K, Kawano K, Noda K, Yoshikawa H for MINT Study Group
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 44 Pages: 1000-1003

    • DOI

      10.1093/jjco/hyu097. Epub 2014 Aug 6.

    • Peer Reviewed
  • [Journal Article] 未来の医療を創る臨床試験―計画・実行の勧め―2014

    • Author(s)
      吉川裕之
    • Journal Title

      日本産婦人科学会雑誌

      Volume: 66 Pages: 1948-1957

    • Peer Reviewed
  • [Journal Article] 卵巣癌の治療と妊孕性温存2014

    • Author(s)
      佐藤豊実、志鎌あゆみ、道上大雄、吉川裕之
    • Journal Title

      産科と婦人科

      Volume: 81 Pages: 1237-1242

  • [Journal Article] 産婦人科領域 この10年の進歩2014

    • Author(s)
      吉川裕之
    • Journal Title

      内科

      Volume: 114 Pages: 1132-1136

  • [Presentation] 産婦人科疾患と臨床用語2014

    • Author(s)
      吉川裕之
    • Organizer
      2014年度医師事務作業補助者指導者養成講習会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-15 – 2014-11-15
    • Invited
  • [Presentation] Human papillomavirus (HPV) testing for women treated for CIN2/3 predicts recurrent or residual diseases: a systematic review.2014

    • Author(s)
      Onuki M, Matsumoto K, Nakao S, Sakurai M, Ochi H, Minaguchi T, Satoh T, Yoshikawa H.
    • Organizer
      The 15th Biennial Meeting of the International Gynecologic Cancer Society
    • Place of Presentation
      Melbourne, Australia,
    • Year and Date
      2014-11-08 – 2014-11-11
  • [Presentation] Delivery delay with neoadjuvant chemotherapy for patients with FIGO stage Ib1 cervical cancer during pregnancy: A report of two cases.2014

    • Author(s)
      Tenjimbayashi Y, Minaguchi T, Matsumoto K, Sakurai M, Onuki M, Ochi H, Obata M, Satoh T, Hamada H, Yoshikawa H.
    • Organizer
      The 15th Biennial Meeting of the International Gynecologic Cancer Society
    • Place of Presentation
      Melbourne, Australia,
    • Year and Date
      2014-11-08 – 2014-11-11
  • [Presentation] Recurrence patterns of gastric-type adenocarcinoma (GAS) of the uterine cervix: A subset analysis of the gynecologic cancer study group of the Japan Clinical Oncology Group (JCOG) GAS multicenter study,2014

    • Author(s)
      Nishio S,Mikami Y,Otsuki T,Yaegashi N,Satoh T,Yoshikawa H,Saitoh M,Okamoto A,Kasamatsu T,Miyamoto T,Shiozawa T,Yoshioka Y,Konishi I,Kojima A,Takehara K,Kaneki E,Kobayahi H,Ushijima K,Kamura T.
    • Organizer
      European Society for Medical Oncology, ESMO 2014
    • Place of Presentation
      Madrid,Spain
    • Year and Date
      2014-09-26 – 2014-09-30
  • [Presentation] 子宮頸癌とHPV ー本邦でのワクチン接種開始までー2014

    • Author(s)
      吉川裕之
    • Organizer
      第2回臨床研究教育セミナー
    • Place of Presentation
      宮城
    • Year and Date
      2014-07-25 – 2014-07-25
    • Invited
  • [Presentation] 新規9価HPV L1ウイルス様粒子ワクチンの16~26歳女性における有効性及び免疫原性2014

    • Author(s)
      澤田美由紀、吉川裕之、野田起一郎、田中宜之、Erin Moeller, Michael Ritter, Oliver Bautista, Joshua Chen, Alain Luxembourg
    • Organizer
      第56回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      栃木
    • Year and Date
      2014-07-17 – 2014-07-19
  • [Presentation] 新規9価HPV L1ウイルス様粒子ワクチンの16~26歳女性における安全性及び忍容性2014

    • Author(s)
      田中宜之、吉川裕之、野田起一郎、澤田美由紀、Erin Moeller, Michael Ritter, Oliver Bautista, Joshua Chen, Alain Luxembourg.
    • Organizer
      第56回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      栃木
    • Year and Date
      2014-07-17 – 2014-07-19
  • [Presentation] 子宮頸がんと卵巣がんにおけるNeoadjuvant Chemotherapy2014

    • Author(s)
      吉川裕之
    • Organizer
      第22回鴨和腫瘍カンファレンス
    • Place of Presentation
      京都
    • Year and Date
      2014-06-15 – 2014-06-15
  • [Presentation] A cohort study of gastric-type adenocarcinoma (GAS) of the uterine cervix: Multi-institutional study by Gynecologic Cancer Study Group of the Japan Clinical Oncology Group (JCOG).2014

    • Author(s)
      Nishio S, Mikami Y, Otsuki T, Yaegashi N, Satoh T, Yoshikawa H, Saito M, Okamoto A, Kasamatsu T, Miyamoto T, Shiozawa T, Yoshioka Y, Konishi I, Kojima A, Nogawa T, Kaneki E, Kobayashi H, Uhsijima K, Kamura T.
    • Organizer
      50th Annual Meeting of American Society Of Clinical Oncology
    • Place of Presentation
      Chicago, Illinois
    • Year and Date
      2014-05-30 – 2014-06-03
  • [Presentation] Comparison of treatment invasiveness between upfront debulking surgery versus interval debulking surgery following neoadjuvant chemotherapy for stage III/IV ovarian, tubal, and peritoneal cancers in phase III randomized trial: JCOG0602. ASCO 2014,2014

    • Author(s)
      Onda T, Yoshikawa H, Shibata T, Nakamura K, Satoh T, Saito T, Kasamatsu T, Nakanishi T, Nogawa T, Saitou M, Ushijima K, Kobayashi H, Takano T, Kawana K, Yokota H, Takano M, Takeshima N, Yaegashi N, Konishi I, Kamura T, japan clinical Oncology Group.
    • Organizer
      50th Annual Meeting of American Society Of Clinical Oncology
    • Place of Presentation
      Chicago, Illinois
    • Year and Date
      2014-05-30 – 2014-06-03
  • [Presentation] 未来の医療を創る臨床試験―計画・実行の勧め―2014

    • Author(s)
      吉川裕之
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-18 – 2014-04-20
  • [Presentation] 子宮頸部「胃型腺癌」の後方視的研究2014

    • Author(s)
      西尾 真、牛嶋公生、嘉村敏治、三上芳喜、大槻健郎、八重樫伸生、佐藤豊実、吉川裕之、笠松高弘、斎藤元章、岡本愛光、宮本 強、塩沢丹里、吉岡弓子、小西郁生、小島淳美、野河孝充、兼城英輔、小林裕明
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-18 – 2014-04-20
  • [Presentation] ヒトパピローマウイルス(HPV)L2 タンパク質の交差性中和エピトープの解析2014

    • Author(s)
      中尾砂里、松本光司、近藤一成、吉川裕之
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-18 – 2014-04-20
  • [Presentation] 免疫抑制剤投与中の関節リウマチ患者に発生した子宮頸部類基底細胞癌の一例2014

    • Author(s)
      小宮春奈、越智寛幸、中尾砂里、櫻井 学、小貫麻美子、水口剛雄、松本光司、佐藤豊実、吉川裕之
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-18 – 2014-04-20

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Published: 2016-06-01  

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