2015 Fiscal Year Final Research Report
Analysis of the functions of a molecular chaperon HSP70 during pregnancy, and attempt to find new treatments of premature labor.
| Project/Area Number |
25670696
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 分子シャペロン |
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| Outline of Final Research Achievements |
Teprenone has been reported to have an effect to induce HSP70. We tried to analyze whether Teprenone is effective or not to prevent preterm labor. At first, we used choriocarcinoma cell line, BeWo. We tried to measure HSP70 concentration in the culture supernate of BeWo. However, we could not detect it in analyzable concentration. Other cell lines, JAR, JEG-3, showed similar results. Next, we tried to analyze the effect of Teprenone on the invasive and proliferative capacity of BeWo, which also was not significant. We tried to detect the expression of HSP70 on placenta of mouse with immunohistochemical staining. However, only non-specific pattern was observed. We could not proceed to the analysis on human materials.
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| Free Research Field |
周産期医学
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