A master regulator, SATB1, regulates genes expressions in head and neck cancers

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670713
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Kanazawa University
• Principal Investigator: Satoru Kondo 金沢大学, 大学病院, 助教 (70436822)
• Co-Investigator(Kenkyū-buntansha): WAKISAKA Naohiro 金沢大学, 大学病院, 講師 (70377414)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: SATB1 / LMP1 / EBV / 上咽頭癌 / 細胞増殖

Outline of Final Research Achievements

SATB1 is a master regulator that regulates thousand kinds of gene expressions. SATB1 associates cancer progression, invasion, and metastasis in mammalian cancer. SATB1 activates various gene expressions in mammalian cancer. However, there has been no reports that examine SATB1 expression in head and neck cancer.
In this study, we found that Epstein-Barr virus latent membrane protein-1 (EBV-LMP1) expression correlates with SATB1 expression in sample tissues with nasopharyngeal carcinoma. Moreover, we found EBV-LMP1 induces SATB1 expression in epithelial cell lines. In addition, SATB1 induced by EBV-LMP1 correlates transformation and anti-apoptosis. Finally, we also examined that SATB1 expression in other head and neck cancers and we found that SATB1 expression level of oropharygeal cancer (OPC) is higher than that of other cancers.　These finding suggest SATB1 associates cancer progression, invasion, and metastasis in head and neck cancers.

Free Research Field

耳鼻咽喉科