Study of conceal burrier function and application for regenerative medicine

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670731
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Osaka University
• Principal Investigator: Tsujikawa Motokazu 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (70419472)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 膠様滴状角膜ジストロフィ / TACSTD2 / 再生医療 / 遺伝子治療 / モデル動物

Outline of Final Research Achievements

Cornea is important tissue which function is burrier function and it must keep transparency. Gelatinous drop-like corneal dystrophy (GDLD) is severe corneal dystrophy in which burrier function is disrupted and patients are suffered from corneal opacity. We have successfully identified the responsible gene for GDLD, TACSTD2. We made knock out mouse line of TACSTD2 and obtained corneal opacity phenotype like in human. Aged mouse (over 1 year) showed significant increased frequency of sever corneal opacity in TACSTD2 knock out. We have successfully cultured the corneal epithelium cells from the mouse and try to develop the new therapy that is the combination therapy of regenerative medicine and gene therapy.

Free Research Field

再生医療