Development of a new treatment for salt-sensitive hypertension by improvement of the lymphatic system

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670748
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: MIZUNO Risuke 東京大学, 農学生命科学研究科, 特任准教授 (30273080)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: リンパ管 / 平滑筋 / 食塩 / 高血圧 / 微小循環

Outline of Final Research Achievements

To identify roles of lymphatic circulation for salt-sensitive hypertension, we investigated the effect of a high salt diet (HSD) on mechanical function and contractility of collecting lymphatics in ex vivo studies. A HSD significantly enhanced contractility and pump activity of afferent lymphatics of SD rat iliac lymph nodes. Efferent, but not afferent, lymphatics of ICR mice iliac lymph nodes significantly increased the frequency and pump activity in response to HSD. A HSD altered responsiveness of osmolality dependent Cl- channels and TRPV channels. The present study indicates that the lymphatic system could adapt to compensate for increase in lymph flow and/or pressure after high salt loading.

Free Research Field

生理学