2013 Fiscal Year Final Research Report
Analysis of molecular sysytem of vascular malformations in relation to nerve and hemo-dynamics
| Project/Area Number |
25670751
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | 血管奇形 / 動静脈奇形 / 神経系 / 細胞 / 虚血 / 組織弁 |
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| Research Abstract |
Vascular malformation is a limit of quality of life, such as limited range of motion and headache admit. Because studies have examined systematically the correlation of peripheral nerves and blood vessels , blood vessels of the circulatory system peripheral tissues and hemo- dynamics. 1. For blood flow added to the tissue to the ischemic model , the involvement of the system " nerve " , and compared with the fat stem cell population adapter of cell membrane receptor tyrosine kinase domain ( junction ) molecules (Shc -adopter protein) knockout mouse model using. 2. As a result of considering the relationship between the wound and angiogenesis and nerve regeneration, one in the lower extremities 20Gy irradiation after iliac artery ligation rat model. It is necessary to investigate further as vascular malformation approximate model by nerve -binding protein genetically engineered mouse models and ischemic rat vascular system operation.
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[Journal Article] One-stage, simultaneous skin grafting with artificial dermis and basic fibroblast growth factor successfully improves elasticity with maturation of scar formation2013
Author(s)
Hamuy R, Kinoshita N, Yoshimoto H, Hayashida K, Houbara S, Nakashima M, Suzuki K, Mitsukawa N, Mussazhanova Z, Kashiyama K, Hirano A, Akita S
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Journal Title
Wound Repair Regen
Volume: 21
Pages: 141-154
Peer Reviewed
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[Book] Imaging, vascular assessment : Extension in depth and vascular anomalies, Skin Necrosis(Eds. Teot L, Meaume S, Del Mamol V, Akita S, Ennis WI)
Author(s)
Akita S, Houbara S, Akatsuka M
Publisher
Springer-Verlag, Heidelberg,(in press)
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