2013 Fiscal Year Final Research Report
Development of early diagnostic method that differentiates pediatric acute encephalopathy using mass spectrometry
| Project/Area Number |
25670760
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
KOIKE Kaoru 京都大学, 医学(系)研究科(研究院), 教授 (10267164)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAKAWA Keiko 日本医科大学, 医学部, 助教 (30165162)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIYAMA Tsuyoshi 東京工芸大学, 工学部, 准教授 (80449032)
ASANO Takeshi 日本医科大学, 医学部, 准教授 (70277490)
OHNO Youkichi 日本医科大学, 医学(系)研究科 (研究院), 教授 (70152220)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | 集中治療医学 |
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| Research Abstract |
In children, it is difficult to distinguish "febrile seizure" from "acute encephalopathy" in the early phase. Our technique using proton nuclear magnetic resonance (NMR) spectra could differentiate cerebrospinal fluid (CSF) obtained from patients with acute encephalopathy, complex febrile seizures and simple febrile seizures. In the present study, we used our technique, analyzed CSF mass spectrometric (MS) data in the similar way and acquired a reasonable result. This technique proved to be a novel signal processing method that comprehensively handles the signal of electromagnetic waves obtained from complex mixture.
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