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2014 Fiscal Year Final Research Report

Development of the new method to control the resorption of alveolar bone, targeting receptor acting on bone - nervous system

Research Project

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Project/Area Number 25670817
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionOsaka University

Principal Investigator

YATANI HIROFUMI  大阪大学, 歯学研究科(研究院), 教授 (80174530)

Co-Investigator(Kenkyū-buntansha) EGUSA Hiroshi  東北大学, 大学院歯学研究科, 教授 (30379078)
Project Period (FY) 2013-04-01 – 2015-03-31
Keywords破骨細胞 / 骨吸収抑制 / コリン作動系
Outline of Final Research Achievements

Severe resorption of alveolar bone after tooth loss/extraction, makes it difficult to restore the missing teeth with dental implants or prosthodontic approaches. Bone resorption is the unique function of the osteoclast, and anti-resorption therapy to date has targeted this cell. Objectives of this study is to investigate the involvement of MLA in osteoclastogenesis. MLA significantly inhibited the formation of TRAP-positive multinucleated osteoclasts in a concentration-dependent manner. These results suggest, that MLA suppresses osteoclastogenesis and that application of MLA enables to promote new bone formation. These findings represent MLA may be useful for therapeutic strategies against alveolar bone resorption in prosthetic treatments.

Free Research Field

歯科補綴学

URL: 

Published: 2016-06-03  

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