Development of the new method to control the resorption of alveolar bone, targeting receptor acting on bone - nervous system

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670817
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Osaka University
• Principal Investigator: YATANI HIROFUMI 大阪大学, 歯学研究科(研究院), 教授 (80174530)
• Co-Investigator(Kenkyū-buntansha): EGUSA Hiroshi 東北大学, 大学院歯学研究科, 教授 (30379078)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 破骨細胞 / 骨吸収抑制 / コリン作動系

Outline of Final Research Achievements

Severe resorption of alveolar bone after tooth loss/extraction, makes it difficult to restore the missing teeth with dental implants or prosthodontic approaches. Bone resorption is the unique function of the osteoclast, and anti-resorption therapy to date has targeted this cell. Objectives of this study is to investigate the involvement of MLA in osteoclastogenesis. MLA significantly inhibited the formation of TRAP-positive multinucleated osteoclasts in a concentration-dependent manner. These results suggest, that MLA suppresses osteoclastogenesis and that application of MLA enables to promote new bone formation. These findings represent MLA may be useful for therapeutic strategies against alveolar bone resorption in prosthetic treatments.

Free Research Field

歯科補綴学