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2014 Fiscal Year Final Research Report

The development of the method of control of periimplant bone remodeling through the control of osteoclast differentiation.

Research Project

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Project/Area Number 25670823
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionKyushu University

Principal Investigator

AYUKAWA YASUNORI  九州大学, 大学病院, 講師 (50304697)

Co-Investigator(Kenkyū-buntansha) KOYANO Kiyoshi  九州大学, 大学院歯学研究院, 教授 (50195872)
TAKAHASHI Akira  九州大学, 大学院歯学研究院, 助教 (60637924)
Project Period (FY) 2013-04-01 – 2015-03-31
Keywords歯科インプラント / 破骨細胞 / 骨 / 歯科補綴学
Outline of Final Research Achievements

In the present study, we intended to regulate periimplant bone resorption with the control of osteoclast development and function. In vitro study revealed that ciglitazone, fluvastatin, denosumab, odanacatib and pantoprazole can regulate osteoclastic bone resorption. In addition when the expression of M-Sec gene, which regulated tunneling nanotube formation, was interfered, osteoclast formation was suppressed. Among them we applied fluvastatin for in vivo study and local administration of fluvastatin to the tissue around the implant placed in rat jaw bone augmented the bone volume, bone-implant contact, and the thickness of periimplant gingiva.

Free Research Field

歯科補綴学

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Published: 2016-06-03  

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