Development of new approach for effective bone repair using small natural compounds and sustained-relesing nanogel

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670831
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Japan Women's University
• Principal Investigator: OTA Masato 日本女子大学, 家政学部, 准教授 (70313228)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 天然低分子化合物 / ホノキオール / 効率的骨修復法 / 徐放性ゲル / nanogel / Bmp２ / 個体差の解消 / 超高齢化社会

Outline of Final Research Achievements

Accompanied by the rapid progress of the super-aging society , the risk of osteoporosis and/or bone fracture, which is related to degradation of quality of life or secondary iatrogenic disease due to long-term hospitalization, is becoming a social problem. To prevent this problem,development of efficient bone regeneration method is an very important and urgent issue for the Japanese people in general. We have developed a new bone regeneration method which combined the honokiol,extracted from magnolia that has been used since ancient times in Japnease medicine,and BMP2 protein and applied to a bone defect using nanogels.This method eliminated the individual differences , yet efficiently to promote bone regeneration. Further, in the present project , we conducted the development of in vitro or in vivo assay systems to analyze the detailed functional mechanism of new bone regeneration method including Honokiol.

Free Research Field

食物生物学