Investigation of novel antiangiogenic therapy against oral cancer targeting synaptic adhesion molecules

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670843
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: University of Tsukuba
• Principal Investigator: YANAGAWA Toru 筑波大学, 医学医療系, 准教授 (10312852)
• Co-Investigator(Kenkyū-buntansha): KATSUHIKO Tabuchi 信州大学, 医学部, 教授 (20546767)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: シナプス接着因子 / ニューロリギン / ニューレキシン

Outline of Final Research Achievements

Synaptic adhesion molecules are cell adhesion factors that modulate synaptic formation and function through interaction of molecules by the extracelluar domain. Recent study showed some synaptic adhesion molecules regulated during vessel remodeling and form endogenous complexes. Then, we focused angiogenesis of oral cancer, and we investigated if we can use synaptic adhesion molecules as novel molecular target for antiangiogenic therapy for oral cancer. We investigated the relation between the expression of synaptic adhesion molecules and clinical factors of oral cancer. On the other hand we investigated molecular basis of synaptic adhesion molecules by using biochemical and developmental biological methods, such as in utero electroporation. We found there was significant difference in prognosis, however, supportive result which suggest abnormal angiogenic change was not obtained by in vivo experiment.

Free Research Field

口腔外科学