2014 Fiscal Year Final Research Report
Genome-wide association study identifies novel temporomandibular joint osteoarthritis susceptibility loci
| Project/Area Number |
25670881
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAKI Koutaro 昭和大学, 歯学部, 教授 (80219295)
KIMURA Ryosuke 琉球大学, 亜熱帯島嶼科学超域研究推進機構, 准教授 (00453712)
INOUE Ituro 国立遺伝学研究所, 総合遺伝研究系, 教授 (00192500)
TOMOYASU Yoko 昭和大学, 歯学部 (50551206)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ゲノムワイド関連解析 / 変形性関節症 / 遺伝（子） |
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| Outline of Final Research Achievements |
We have conducted the first GWAS to identify susceptibility genes underlying degenerative bony changes of the TMJ that were diagnosed by examination of a panoramic radiograph and/or MRI and/or CT images. As a result, 41 SNPs located in 22 independent loci showing association signals with degenerative bony changes of the TMJ. Our data may be useful for a future meta-analysis of
GWAS data sets.
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| Free Research Field |
歯科矯正学
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