Sirt3 might be a key molecule linking circadian rhythm to aging

2015 Fiscal Year Final Research Report

• Project/Area Number: 25702005
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Eating habits
• Research Institution: National Agriculture and Food Research Organization
• Principal Investigator: Oike Hideaki 国立研究開発法人農業・食品産業技術総合研究機構, その他部局等, 主任研究員 (30455307)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 老化 / 概日リズム / エネルギー代謝 / 栄養 / 体内時計 / 乳酸菌

Outline of Final Research Achievements

We found that a chronic shift in light/dark (LD) cycles induced obesity without increasing food intake in mice. Mice fed at a fixed 12 h under the LD shift did not develop symptoms of obesity despite isocaloric intake. These results suggest that disruption of circadian food intake induces obesity.
We demonstrated that intake of Lactococcus lactis subsp. cremoris H61 for 6 months prevented age-related hearing loss in C57BL/6J mice. Analysis of plasma revealed correlation between fatty acids and hearing ability, leading to a novel biomarker for aging.

Free Research Field

食品機能学、時間生物学、老化、栄養学