Simulation on tissue formation through intercellular interaction

2015 Fiscal Year Final Research Report

• Project/Area Number: 25702025
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kyoto University
• Principal Investigator: Inoue Yasuhiro 京都大学, 再生医科学研究所, 准教授 (80442929)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 細胞間相互作用 / メカノフィードバック / メカノセンシング / 数理モデル / 形態形成

Outline of Final Research Achievements

In this study, we focused on a mechano-feedback at an intercellular adhesion machinery. At cellular-to-tissue level, we constructed a mathematical model expressing the feedback, and performed simulations on a growing spheroid-like tissue. These simulations revealed that continuous modifications through mechano-feedback are necessary for maintaining a smooth apical surface. At molecular level, we constructed a physical model for explaining actin-based mechano-sensing that is one of necessary components at the mechano-feedback. The model captured the qualitative and quantitative responses of actin-binding proteins to the forces, as observed experimentally. We theoretically suggested that actin-binding proteins can show different kinetic responses even to the same mechanical signal (tension).

Free Research Field

メカノバイオロジー