2016 Fiscal Year Final Research Report
Chemical genetics for understanding structure and function of cell membranes
| Project/Area Number |
25702048
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 天然物化学 / 生体膜 / 脂質 / 化学遺伝学 |
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| Outline of Final Research Achievements |
So far, a large number of natural products (around half a million) has been catalogued in databases. They show unique, complex chemical structures, which make themselves as attractive resources for drug candidates and research tools. In this research project, we have worked on natural products with a molecular function of ‘membrane binding’. This is because a variety of chemotypes has been and will be disclosed to have unique interactions with cell membranes. In addition, research tools are requisite for deeper understanding of the cell membrane. Finally, we have to remember that the cell membrane is one of the major targets of antimicrobials. In this project, we discovered several new natural products and revealed their molecular functions. Functions and regulation mechanisms of membrane lipids were investigated using them as chemical tools. In summary, we successfully demonstrated that chemical genetics is a powerful approach for investigating cell membranes.
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| Free Research Field |
天然物化学
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