2015 Fiscal Year Final Research Report
Integration of Transport Functions into Arrayed Cell-Sized Proteoliposomes
Project/Area Number |
25706015
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Nano/Microsystems
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Research Institution | Kanagawa Academy of Science and Technology |
Principal Investigator |
OSAKI TOSHIHISA 公益財団法人神奈川科学技術アカデミー, 人工細胞膜システムグループ, 研究員 (50533650)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 生体機能模倣 / 生体分子(膜タンパク質) / 脂質 / マイクロ・ナノデバイス / 合成生物学 |
Outline of Final Research Achievements |
In former works, liposome, formed with a lipid bilayer, has been applied for the membrane of cell models; the membrane passively diffuses membrane-soluble molecules or water but unable to respond to the external stimuli. In this study, we therefore developed an array of functional proteoliposomes with a controlled cellular size. Our previously developed method, the precise micropatterning of lipids on a substrate, was further adjusted for the proteoliposome formation. The functions of membrane proteins were examined on the proteoliposome array obtained. As the next step, we plan to implement stimuli-responsive behavior into the proteoliposome array.
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Free Research Field |
脂質膜、材料・表面化学、微細加工技術
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