Investigation of angiogenesis mechanism after central nervous system injury

2015 Fiscal Year Final Research Report

• Project/Area Number: 25710006
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Osaka University
• Principal Investigator: Muramatsu Rieko 大阪大学, 医学(系)研究科(研究院), 准教授 (90536880)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 軸索 / 血管 / 多発性硬化症

Outline of Final Research Achievements

Injury and inflammation mediate disruption of neuronal network. Because disruption of neuronal network is involved in neuronal dysfunction, recovery from neuronal dysfunction is considered to require reconstruction of disrupted neuronal network after injury. Although the repair mechanism of neuronal network has been unknown, previous our study suggested that neovessels formed though inflammation promotes rewiring of neuronal network in damaged central nervous system (CNS). In the present study, we investigated the mechanism of neovessel formation which is crucial for rewiring of CNS network. We found that degeneration of neuronal network precedes angiogenesis after CNS inflammation. We tried to identify the factor which is released from degenerating neuron that promotes angiogenesis, and we succeeded to identify the key factor that promotes proliferation of vascular endothelial cells.

Free Research Field

神経科学、神経化学・神経薬理学