Sequence-based Cancer-stromal Interactome Analysis for Accessible Therapeutic Targets

2015 Fiscal Year Final Research Report

• Project/Area Number: 25710020
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Medical genome science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: SHUMPEI ISHIKAWA 東京医科歯科大学, 難治疾患研究所, 教授 (50418638)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA Masato 東海大学, 医学科基盤診療学系, 教授 (00164335)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ゲノム / がん / 治療標的

Outline of Final Research Achievements

We established the method of analyzing the entire cancer cell-stromal cell interaction (interactome) from the transcriptome sequence data of cancer xenograft tissues, by accurate separation of human and mouse sequence. Using this method, we analyzes the xenograft established from various type of cancer cells and clinical cancer tissues. We successfully confirmed that the interactome profile well reflects the actual histology of the cancer, and identified the candidate important interactions in a particular cancer subtype. For some of candidate molecules we could confirmed their tumor-specific and stroma-specific localization in actual clinical cancer tissues.

Free Research Field

病理学　ゲノム科学