Sympatho-adrenal morphogenesis and interaction with blood vessels

2016 Fiscal Year Final Research Report

• Project/Area Number: 25711015
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Developmental biology
• Research Institution: Tohoku University
• Principal Investigator: Saito Daisuke 東北大学, 学際科学フロンティア研究所, 助教 (90403360)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 副腎 / 副腎皮質 / 副腎髄質 / 生殖腺 / 血管 / ニワトリ胚

Outline of Final Research Achievements

In adult animals, the autonomic nervous system and endocrine organs act as the major units to maintain homeostasis. However, it remains elusive how these functional units are formed during embryonic development. In this research, I have worked in order to reveal the mechanism underling lineage segregation of sympathetic neurons (autonomic nervous system) and adrenal medulla (endocrine tissue), the cell lineages of adrenal cortex and gonad, and the mechanism underling the formation of gonad. I have found that Cv-2 gene is involved in the lineage segregation of sympathetic neurons and adrenal medulla, the adrenal cortex and gonad are derived from the different origins, and Shh gene act as the trigger to promote gonadogenesis. I have already published two works and submitted one as research papers.

Free Research Field

発生生物学