Functional analysis of stem cell glycans and development of novel glycan engineering technologies for regenerative medicine

2015 Fiscal Year Final Research Report

• Project/Area Number: 25712039
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Applied molecular and cellular biology
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Tateno Hiroaki 国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 主任研究員 (30450670)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 糖鎖 / レクチン / 幹細胞 / 再生医療

Outline of Final Research Achievements

hiPSCs and hESCs have abilities to proliferate eternally (self-renewal) and differentiate into any cell types such as cardiomyocytes and neurons (pluripotency). Therefore, hiPSCs and hESCs gain a lot of attentions as cell sources for regenerative medicine. I have discovered a hiPSC/hESC-specific lectin called rBC2LCN. In this study, I analyzed the binding mechanisms of rBC2LCN to hiPSCs/hESCs, clarified the functions of glycans recognized by the lectin, and developed technologies to detect and eliminate undifferentiated cells.

Free Research Field

糖鎖生物学