2015 Fiscal Year Final Research Report
Elucidation of the molecular mechanism of engulfment by cardiac myofibroblast in myocardial infarction
| Project/Area Number |
25713007
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
Michio Nakaya 九州大学, 薬学研究科(研究院), 准教授 (80464387)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 筋線維芽細胞 |
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| Outline of Final Research Achievements |
After myocardial infarction occurs, many cardiomyocytes receiving blood supply from occluded blood vessels die. However, the molecular mechanisms underlying engulfment of dead cells in myocardial infarction still remain largely unknown. We found that cardiac myofibroblasts that have been known to exert fibrosis engulf the dead cells in myocardial infarction. We also revealed that engulfment by cardiac myofibroblasts depends on MFG-E8.
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| Free Research Field |
分子生物学、薬理学
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