2016 Fiscal Year Final Research Report
Construction of artificial bone marrow microenvironment that maintains undifferentiated state of hematopoietic stem cells
| Project/Area Number |
25713037
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 造血幹細胞 / 幹細胞ニッチ |
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| Outline of Final Research Achievements |
Hematopoietic stem cells are maintained undifferentiated in the bone marrow microenvironment. However, we have not yet fully enabled the control of hematopoietic stem cells. We found heterogeneity of amino acid concentration in bone marrow, and analyzed function of each amino acid and hematopoietic stem cell. As a result, the hematopoietic stem cells quickly disappeared under the culturing condition of valine deficiency, and the reduction of hematopoietic stem cells in vivo was confirmed by giving the valine-deficient diet to the mouse for a long time. In addition, interesting results were obtained that transplantation of hematopoietic stem cells was established without irradiation by giving valine-deficient diet to recipient mice, and the article was accepted in Science Journal Science of the United States of America (Taya et al., 2016).
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| Free Research Field |
血液内科学、幹細胞生物学
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