2015 Fiscal Year Final Research Report
Screening of novel molecules that regulate the histone deacetylase activity from foods and development of nerve regeneration treatment
| Project/Area Number |
25750059
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Yamanashi Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | HDAC / アントシアニジン / 神経保護効果 / 神経突起伸長 / ヒストンアセチル化 / ｐ53 |
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| Outline of Final Research Achievements |
We found that cyanidin and peonidin inhibited histone deacetylase (HDAC) and increased histone acetylation. Using a primary culture neuronal cells and SH-SY5Y cell lines to consider the effect on the neuronal cell protective effect and the neurite outgrowth. Cyanidin and peonidin protected SH-SY5Y cells from endoplasmic reticulum stress, and promoted neuronal outgrowth in primary cultured neuronal cells. Cyanidin and peonidin decreased CHOP expression and increased GAP-43 expression. On the other hand acetylated p53 localized to the nucleus. Our data suggests that the neuroprotection and neurite elongation by cyanidin and peonidin might be involved in acetylation of histone and p53.
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| Free Research Field |
神経科学、食品科学、生化学
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