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2016 Fiscal Year Final Research Report

Fundamental research for constructing a new physical therapy strategy for widesprear chronic pain after physical immobilizaiton

Research Project

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Project/Area Number 25750237
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionAichi Medical University

Principal Investigator

Ohmichi Yusuke  愛知医科大学, 医学部, 講師 (50506673)

Project Period (FY) 2013-04-01 – 2017-03-31
Keywords不動化 / ミクログリア / アストロサイト / 酸化ストレス / 神経原性炎症 / 不快情動
Outline of Final Research Achievements

In order to construct a new physiotherapy strategy for widespread chronic pain after physical immobilization, we analyzed pathophysiological mechanism using our chronic post-cast pain (CPCP) model. We found that oxidative damage, caused by two weeks cast immobilization, occurred in a wide area (muscle, muscle spindle and the like) of the immobilized hind limb. Also, our findings suggested the following: ①the oxidative damage induced hyper excitability of nociceptive neurons and neurogenic inflammation in the immobile limb; ②the neuropeptide signal generated by this neurogenic inflammation causes hyper-excitation of spinal dorsal horn neurons and causes central sensitization; ③ the behavior of mechanical hyperalgesia in the chronic phase is secondary to oxidative impairment in immobile limb.

Free Research Field

理学療法,慢性疼痛

URL: 

Published: 2018-03-22  

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