Fundamental research for constructing a new physical therapy strategy for widesprear chronic pain after physical immobilizaiton

2016 Fiscal Year Final Research Report

• Project/Area Number: 25750237
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Aichi Medical University
• Principal Investigator: Ohmichi Yusuke 愛知医科大学, 医学部, 講師 (50506673)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 不動化 / ミクログリア / アストロサイト / 酸化ストレス / 神経原性炎症 / 不快情動

Outline of Final Research Achievements

In order to construct a new physiotherapy strategy for widespread chronic pain after physical immobilization, we analyzed pathophysiological mechanism using our chronic post-cast pain (CPCP) model. We found that oxidative damage, caused by two weeks cast immobilization, occurred in a wide area (muscle, muscle spindle and the like) of the immobilized hind limb. Also, our findings suggested the following: ①the oxidative damage induced hyper excitability of nociceptive neurons and neurogenic inflammation in the immobile limb; ②the neuropeptide signal generated by this neurogenic inflammation causes hyper-excitation of spinal dorsal horn neurons and causes central sensitization; ③ the behavior of mechanical hyperalgesia in the chronic phase is secondary to oxidative impairment in immobile limb.

Free Research Field

理学療法，慢性疼痛