Microwave-assisted Rapid Fabrication of Monolithic Stationary Phases for Capillary Liquid Chromatography

2015 Fiscal Year Final Research Report

• Project/Area Number: 25810085
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Analytical chemistry
• Research Institution: Gifu University
• Principal Investigator: Lim Lee Wah 岐阜大学, 工学部, 准教授 (80377689)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: キャピラリーモノリス固定相 / 迅速・簡便調製法 / マイクロ波 / ポロゲンレス調製法 / マレイン酸系モノリスカラム

Outline of Final Research Achievements

Monolithic columns, which consist of μm-sized skeletons and through-pores, could offer high separation efficiency with ultra low flow resistance, and they have attracted much attention since their introduction in the early 1990s. In this research, rapid fabrication of monolithic silica- and polymer-based capillary columns was evaluated using microwave irradiation. The reaction solution was filled into fused-silica capillary tubing and the column was then irradiated at different time under various temperature and output control of the microwave device. The morphology of the monoliths was observed with a scanning electron microscope and was compared to those monoliths that were fabricated under normal thermal conditions. The results showed that the degree of output of the microwave device had direct influence on the morphology as well as size of the skeleton backbone of the monoliths.

Free Research Field

化学