2014 Fiscal Year Final Research Report
Molecular basis analysis for the regulation of presynaptic terminal and neural network
| Project/Area Number |
25830008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | アクティブゾーン / シナプス / 神経回路 / 脳機能 / 条件付き遺伝子欠損 / Cre-loxP |
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| Outline of Final Research Achievements |
To understand neural network, it is indispensable to understand the process of synaptic transmission. In this project, I focused on the presynaptic terminal protein called CAST/ELKS, and analyzed brain function of deletion mutants through their synaptic neurotransmission. (1) The deletion mutant of ELKS had little phenotype, probably because its function was complementary supported by CAST. (2) The CAST/ELKS deletion mutants showed various phenotypes depending on the each deficient region of the brain. The results of this project suggested that CAST/ELKS have various mechanisms relating to their located synapse and neural network.
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| Free Research Field |
神経科学
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