Subclass-specific expression of perineuronal nets in parvalbumin-containing GABAergic neurons in the mouse hippocampus

2015 Fiscal Year Final Research Report

• Project/Area Number: 25830035
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kyushu University
• Principal Investigator: Jun Yamada 九州大学, 医学(系)研究科(研究院), 助教 (70582708)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 海馬 / GABAニューロン / ペリニューロナルネット / パルブアルブミン

Outline of Final Research Achievements

The perineuronal nets (PNNs) surround the soma of a subset of neurons, and is considered to play a critical role in regulation of neural plasticity. Seminal works using immuno/lectin histochemistry reported that PNNs were associated with parvalbumin-expressing (PV+) GABAergic neurons. Although later reports have shown that PV+ neurons consist of at least five subclasses (basket cells, axo-axonic cells, bistratified cells, oriens-lacunosum-moleculare (O-LM) cells and hippocampo-septal projection (H-S) cells), the relationship between PNNs and classification of PV+ neurons remains unclear. We clarify whether PNNs are associated with specific subclasses of PV+ neurons in the mouse hippocampus. The vast majority of PV+ basket cells were surrounded by PNNs, while only a minor population of PV+ axo-axonic, O-LM, and H-S cells were enwrapped with PNNs. These data provide evidence that PNNs may critically regulate hippocampal neuronal activity via subclass specific expression in PV+ neurons.

Free Research Field

神経解剖学