2015 Fiscal Year Final Research Report
Regulation of mitochondrial biogenesis and function by necdin-Sirt1 complex
| Project/Area Number |
25830053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ミトコンドリア / 神経変性疾患 / PGC-1alpha / Necdin / パーキンソン病 |
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| Outline of Final Research Achievements |
I examined the regulation of mitochondrial biogenesis and the mechanism of neuroprotection against mitochondrial insults by necdin and PGC-1α. Necdin suppressed PGC-1α degradation via ubiquitin-proteasome pathway to promote mitochondrial biogenesis and to protect neurons against mitochondrial insults.
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| Free Research Field |
総合生物
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