2014 Fiscal Year Final Research Report
Analysis of the molecular mechanism for primordial follicle activation
| Project/Area Number |
25830061
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUZUKI Hitomi 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (60644094)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 原始卵胞 / 卵巣機能 |
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| Outline of Final Research Achievements |
Folliculogenesis in mammals is a complex process involving bi-directional communication between the oocyte and surrounding soma. In the mouse ovary, primordial follicles (PrdFs) that contain 15um oocyte surrounded by flatten soma are formed shortly after birth, and provide a source of future growing follicles during the entire reproductive lifespan. PrdFs remain dormant for prolonged intervals. For retaining a long female reproductivity, it is essential to manage both ‘dormancy’ and ‘activation’ of PrdF and to prevent the consumption of all PrdF in a short period. In this study, we revealed the part of function of Sohlh1 and Sohlhl2, which are the oocyte- specific transcription factors.
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| Free Research Field |
発生生物学
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