2015 Fiscal Year Final Research Report
Pigment epithelium-derived factor as a target for development of new animal model of arteriosclerosis
| Project/Area Number |
25830067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 血管保護作用 / 動脈硬化症 / モデル動物 |
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| Outline of Final Research Achievements |
We identified laminin receptor as a functional receptor for pigment epithelium-derived factor (PEDF) which act atheroprotective. We investigated PEDF exert atheroprotective effects via association with laminin receptor. To investigate how arteriosclerosis develop, we generated laminin receptor transgenic (LR-Tg) mice that ubiquitously express human laminin receptor.
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| Free Research Field |
血管生物学
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