2014 Fiscal Year Final Research Report
Characterization of endothelial side population cells in the tumor vasculature and their potential role for drug resistance.
| Project/Area Number |
25830080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 血管内皮幹細胞 / 腫瘍血管 / 血管新生 |
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| Outline of Final Research Achievements |
Angiogenesis is regarded as a hallmark in cancer development.In the previous work, we identified stem/progenitor like endothelial cell(EC) in the peripheral blood vessel. These endothelial stem-like cell possess EC colony-forming potential in vitro and contribute to angiogenesis by generating functional mature blood vessels in vivo. In this study, we characterized endothelial stem-like cells in the tumor vasculature and found that in the tumor vasclature, the percentage of stem-like cells were higher than normal tissues. We further examined contribution of these cells to the tumor vasculature by transplantation model and found that they produces numbers of ECs and contribute to the tumor blood vessels as functional vessels. Moreover, administration of anti-angiogenic drugs revealed their potential role for resistance to anti-angiogenic therapy.
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| Free Research Field |
血管生物学
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