Construction of mutation analysis pipelines for identifying novel cancer genes

2014 Fiscal Year Final Research Report

• Project/Area Number: 25830139
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical genome science
• Research Institution: The University of Tokyo
• Principal Investigator: UENO Toshihide 東京大学, 医学(系)研究科(研究院), 助教 (40381446)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: バイオインフォマティクス / 次世代シークエンサー / 変異解析

Outline of Final Research Achievements

To elucidate genomic mutation in cancer, we developed computer pipelines which analyzed data provided in a next-generation sequencer. For data of whole-exome sequencing and RNA sequencing, we were able to create the mutation profile list of various cancer tumors and succeeded in identification of novel cancer genes. For example, our pipeline results showed the identification of the genes which became the mechanism of leukemic evolution of donor-derived cells after allogeneic stem cell transplantation.

Free Research Field

バイオインフォマティクス