2015 Fiscal Year Final Research Report
Nuclear IKKbeta regulates necroptosis and hepatocellular carcinoma
| Project/Area Number |
25840035
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 肝障害 / 肝がん / IKK |
|---|
| Outline of Final Research Achievements |
In this study, we aimed to reveal roles of the cytosolic and nuclear IKKβ in decision of cell life and death in vivo. Tg-NLS-IKKβKN IKKβΔhep mice presented with severe liver injury and fibrosis progression. Administration of diethylnitrosamine (DEN) to Tg-NLS-IKKβKN IKKβΔhep mice shown lower a level of hepatocellular carcinoma than that observed in IKKβΔhep mice.
|
| Free Research Field |
分子生物学
|
