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2015 Fiscal Year Final Research Report

Nuclear IKKbeta regulates necroptosis and hepatocellular carcinoma

Research Project

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Project/Area Number 25840035
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional biochemistry
Research InstitutionHiroshima University

Principal Investigator

Tsuchiya Yoshihiro  広島大学, 医歯薬学保健学研究院(医), 助教 (90611301)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords肝障害 / 肝がん / IKK
Outline of Final Research Achievements

In this study, we aimed to reveal roles of the cytosolic and nuclear IKKβ in decision of cell life and death in vivo. Tg-NLS-IKKβKN IKKβΔhep mice presented with severe liver injury and fibrosis progression. Administration of diethylnitrosamine (DEN) to Tg-NLS-IKKβKN IKKβΔhep mice shown lower a level of hepatocellular carcinoma than that observed in IKKβΔhep mice.

Free Research Field

分子生物学

URL: 

Published: 2017-05-10  

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