2015 Fiscal Year Final Research Report
Analysis of regulatory mechanisms in torque generation of the bacterial flagellar motor
| Project/Area Number |
25840054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Hosei University |
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Principal Investigator |
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| Research Collaborator |
KAWAGISHI Ikuro 法政大学, 生命科学部, 教授 (80234037)
YAMAMOTO Kaneyoshi 法政大学, 生命科学部, 教授 (40351580)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 細菌べん毛モーター |
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| Outline of Final Research Achievements |
In this research, we aimed to reveal regulatory mechanisms in torque generation of the bacterial flagellar motor at single molecule level. We have demonstrated that a genetically engineered hybrid-fuel flagellar motor in Escherichia coli that runs on both types of ion gradient, protons and sodium ions, although natural E. coli cells have only proton-driven one. We also found that the hybrid motors regulate the generated torque automatically and dynamically in response to external conditions, by swapping the motor components.
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| Free Research Field |
生物物理学
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