Interactions between organelles and molecules related to autophagosome formation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25840076
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cell biology
• Research Institution: Osaka University
• Principal Investigator: SHIBUTANI Shusaku 大阪大学, 医学(系)研究科(研究院), 助教 (20534473)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: オートファジー / Atg

Outline of Final Research Achievements

It has been known that damage to endosomes or lysosomes induces autophagy, and this autophagy induction appears to be related to the isolation/elimination of invasive bacteria and damaged lysosomes. The ULK1 complex, a protein complex that functions at early stages of autophagy, is known to be recruited to damaged endosomes/lysosomes, suggesting that the recruitment plays a role in the autophagy induction around damaged endosomes/lysosomes. In this study, we focused on FIP200, a subunit of the ULK1 complex, and identified the regions of FIP200 that are responsible for its recruitment to damaged endosomes and for its interaction with ULK1, respectively. We further analyzed the functions of these regions in autophagy induction.

Free Research Field

細胞生物学