2015 Fiscal Year Final Research Report
The analysis of the molecular function of ROS signaling in neuroeplthelium development
Project/Area Number |
25840090
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Developmental biology
|
Research Institution | Doshisha University |
Principal Investigator |
Sakai Daisuke 同志社大学, 研究開発推進機構, 助教 (90632646)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 活性酸素種 / 脳発生 |
Outline of Final Research Achievements |
In this study, I investigated whether reactive oxygen species (ROS) function as signaling molecule on embryonic brain development. Consequently, I revealed that ROS were required for proliferation of neural progenitor cells and consequent neurogenesis. Furthermore, ROS were involved in cranial neural crest development. Tissue specific ROS generation appeared to be dependent on the activity of cellular metabolism, glycolysis, but independent on ROS-generating NADPH oxidases.
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Free Research Field |
発生生物学
|