2016 Fiscal Year Final Research Report
Possible involvement of novel peptides, NMU- and NMS-related peptide, in the hypothalamic function
| Project/Area Number |
25850221
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
MURAKAMI Noboru
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 新規ホルモン / 生理作用 |
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| Outline of Final Research Achievements |
The aim of this study is to clarify the physiological functions of novel peptides, NMU- and NMS-related peptide (NU1 and NU2, respectively) in hypothalamus. The morphological analysis using autoradiography indicated the existence of specific binding sites for novel peptides in the rat brain. Intraventricular (ICV) administration of NU1 and NU2 increased the food intake. During the dark phase, ICV administration of these peptides increased the body temperature. In addition, ICV-injection of NU1 and NU2 affected the locomotor activity and the energy expenditure. These results suggest that NU1 and NU2 play important roles in the hypothalamus.
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| Free Research Field |
内分泌学
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